Purpose
This study investigated the effects of healthy lifestyle interventions (HLSIs) on health-related quality of life (HR-QoL) in childhood and adolescent cancer survivors (CACS).
Methods
Major databases were searched for English-language original articles published between January 1, 2000 and May 2, 2021. Randomized controlled trials (RCTs) and non-RCTs were included. Quality was assessed using the revised Cochrane risk-of-bias tool, and a meta-analysis was conducted using RevMan 5.3 software.
Results
Nineteen studies were included. Significant effects on HR-QoL were found for interventions using a multi-modal approach (exercise and education) (d=-0.46; 95% confidence interval [CI]=-0.84 to -0.07, p=.02), lasting not less than 6 months (d=-0.72; 95% CI=-1.15 to -0.29, p=.0010), and using a group approach (d=-0.46; 95% CI=-0.85 to -0.06, p=.02). Self-efficacy showed significant effects when HLSIs provided health education only (d=-0.55; 95% CI=-0.92 to -0.18; p=.003), lasted for less than 6 months (d=-0.40; 95% CI=-0.69 to -0.11, p=.006), and were conducted individually (d=-0.55; 95% CI=-0.92 to -0.18, p=.003). The physical outcomes (physical activity, fatigue, exercise capacity-VO2, exercise capacity-upper body, body mass index) revealed no statistical significance.
Conclusion
Areas of HLSIs for CACS requiring further study were identified, and needs and directions of research for holistic health management were suggested.

Citations

• Team Survivors: Preliminary Analysis of an Innovative Intervention to Promote Physical Activity in Survivors of Childhood Cancer and Hematopoietic Stem Cell Transplant
  Meghan K. Flannery, Jocelyn Morin, Katrina O’Malley, Debra Schmidt, Jennifer A. Hoag
  Children.2025; 12(4): 399.     CrossRef
• Effectiveness of a healthy lifestyle program based on a mobile serious game for childhood cancer survivors: A quasi-randomized trial
  Kyung-ah Kang, Han-ho Kim, Shin-jeong Kim, In-hye Song, Min-jin Lee, Su-yong Lee, Sae-rom Han, Ki-hyuk Lee, So-won Kim, Hye-rin Nam, Mi-na Park, Hye-min Lee, Hee-jin Yoon
  Journal of Pediatric Nursing.2024; 77: 35.     CrossRef
• Barriers, facilitators, and other factors associated with health behaviors in childhood, adolescent, and young adult cancer survivors: A systematic review
  Ismay A. E. de Beijer, Eline Bouwman, Renée L. Mulder, Philippa Steensma, Morven C. Brown, Vera Araújo‐Soares, Magdalena Balcerek, Edit Bardi, Jeanette Falck Winther, Line Elmerdahl Frederiksen, Marloes van Gorp, Sara Oberti, Rebecca J. van Kalsbeek, Toma
  Cancer Medicine.2024;[Epub]     CrossRef